Dion was born in the Bronx in New York. In his youth he was a member of street gangs in the Bronx. In 1957, he recorded his first album, "The Chosen Few", released on Mohawk Records under the name "Dion and the Timberlanes". Dion sang the vocals apart in, and has never met The Timberlanes. In 1958 he formed together with three friends from the Bronx the doo-wopgroep Dion and the Belmonts. They had a hit with "I Wonder Why", their first single on Laurie Records in the summer of 1958 the number 22 on the Billboard Hot 100 . They followed with "No One Knows" (No. 19) and "Don't Pity Me" (No. 40). Their biggest hit was "A Teenager In Love", which reached the fifth place in the Hot 100.
They performed in American Bandstand and in 1959 they took part in the Winter Dance Party tour, including Buddy Holly, Ritchie Valens and The Big Bopper. When Buddy Holly chartered a plane to from Clear Lake, Iowa to a next action to fly, be Dion a village in the plane because he found too high the price of $ 36.  the unit crashed and the four occupants-the pilot, Buddy Holly, Ritchie Valens and J.P. Richardson (aka The Big Bopper)-died in the crash.
In 1960, Dion and the Belmonts went apart. Dion went on as a solo artist. He let the Doo-Wop behind itself and more profiled as a rock 'n' rolland rhythm-and-blues singer.He scored new hits in 1961 with "Lonely Teenager" and "Runaround Sue", which he co-wrote with Ernie Maresca wrote. The latter single (Laurie Records 3110) reached the top of the Billboard Hot 100 during the week of 28 October 1961. It stayed two weeks at number 1. It was covered by Leif Garrett in 1977. Linda Laurie brought in november 1961 a "answer song" out, "Stay-at-home Sue". 
"Runaround Sue" was followed by the single "The Wanderer" (Laurie 3115), which reached the second place in the Hot 100. "Lovers Who Wander" (Laurie 3123) reached the third place in 1962.
In september 1962 Dion went to Columbia Records. There he had a new hit with the Leiber & Stoller-song "Ruby Baby" (Billboard No. 2). He also appeared in three films:Ten Girls Ago, Teenage Millionaire and Twist Around the Clock. But by a growing ' drinking and intensive drug problem he disappeared from the scene for a while in the Middle 1960s.
In 1969 he found his faith in God and returned to Laurie Records, this time as a folk singer with own material and covers as "From Both Sides Now" and "Purple Haze"."Abraham, Martin & John" was a top 5 hit in the United States.
He went to Warner Bros., where he released four albums from 1970, in which he profiled itself as a classical singer-songwriter. The songs were arranged and often sober was just to hear Dion with his guitar. These albums were not a great success commercially.
In 1972 came together once again the Dion and the Belmonts for a reunion concert in New York's Madison Square Garden.
It appeared In 1975 studio album Born to Be with You, in a production by Phil Spector. Unlike the previous albums was this abundant arranged. The album would eventually come out in the United States, though not in Great Britain.
At the end of that decade was Dion a "Born-Again Christian" and dedicated themselves to the Christian music, with albums like Only Jesus and I Put Away My Idols.
In 1989, the year he in the Rock and Roll Hall of Fame was recorded Dion brought a comeback album, Yo Frankie, produced by Dave Edmunds on Arista Records. A year later he formed the band "The Little Kings", with which he toured on the East coast of the United States.
End of the 1990s he converted again to the Catholic faith. He brought in 2000 the album Déjà Now out, with new songs recorded with the same technique as those in the 1950s and 1960s. This "back to the roots"-trends got a sequel with three traditional blues albums: Bronx in Blue (2006), Son of Skip James (2007) and Tank Full of Blues (2012). Bronx in Blue was nominated for a Grammy Award in the category "Best Traditional Blues".
- Presenting Dion & the Belmonts (1959)
- Wish Upon a Star with Dion and the Belmonts (1960)
- Alone with Dion (1960)
- Runaround Sue (1961, United States no. 11)
- Lovers Who Wander (1962, United States no. 8)
- Love Came to Me (1964)
- Ruby Baby (1963, United States no. 20)
- Donna the Prima Donna (1963)
- Together with the Belmonts (1964)
- Together Again (1967)
- Wonder Where I'm Bound (1968)
- Dion (1968)
- Sit Down Old Friend (1970)
- You're Not Alone (1971)
- Sanctuary (1971)
- Suite for Late Summer (1972)
- Reunion (1973)
- Born to Be with You (1975)
- Streetheart (1976)
- Return of the Wanderer (1978)
- Inside Job (1981)
- Only Jesus (1983)
- I Put Away My Idols (1984)
- Kingdon in the Streets (1985)
- Velvet and Steel (1986)
- Yo Frankie (1989)
- The Road I'm On (A Retrospective) (1997)
- Déjà Now (2000)
- Dion'n'Little Kings Live in New York (2001)
- Under the Influence (2005)
- Bronx in Blue (2006)
- Son of Skip James (2007)
- Heroes: Giants of Early Guitar Rock (2008)
- Tank Full of Blues (2012)
- "I Wonder Why" (1958, United States no. 22)
- "A Teenager in Love" (1959, United States no. 5, UK No. 28)
- "Where or When" (1960, United States no. 3)
- "Lonely Teenager" (1960, United States no. 12, UK No. 47)
- "Runaround Sue"(1961, USA No. 1, UK No. 11)
- "The Wanderer" (1961, United States no. 2, UK No. 10)
- "Lovers Who Wander" (1962, USA No. 3)
- "Little Diane" (1962, United States no. 8)
- "Love Came to Me" (1962, USA No. 10)
- "Ruby Baby" (1963, USA No. 2)
- "Donna the Prima donna" (1963, USA No. 6)
- "Drip Drop" (1963, USA No. 6)
- "Abraham, Martin and John" (1968, United States no. 4)